About the Nova Scotia COVID-19 Health Research Coalition
The Nova Scotia COVID-19 Health Research Coalition is a collaborative partnership between Dalhousie Medical Research Foundation, NSHA Research & Innovation (Nova Scotia Health Authority), Dalhousie University, the QEII Health Sciences Centre Foundation, the IWK Foundation, the IWK Health Centre, the Dartmouth General Hospital Foundation (DGHF) and Research Nova Scotia (RNS).
Together, these partners have committed a collective investment of $1.5 million to support local research projects pursuing solutions to the COVID-19 crisis.
A total of 262 applications were submitted from research teams across the province. The Coalition is pleased to announce that the collective investment of over $1.5 million will be distributed to 40 COVID-19 research teams.
Please join the Coalition in congratulating the funding recipients below.
Dr. Lisa Barrett
Project: Cellular Immune Phenotype in Patients with Severe COVID Disease Before and After COVID-19 Treatment
This study aims to better understand COVID-19 immune disruption and reversibility by examining global and SARS-CoV-2 specific immune dysregulation before, during and after therapy.
Dr. Steven Beyea
Project: NeuroCOVID: a Prospective, Longitudinal MRI Examination of Brain Involvement in COVID-19
This study will use the new 0.5T Magnetic Resonance Imaging scanner at the QEII Health Sciences Centre to determine whether evidence of brain abnormalities among COVID-19 inpatients is associated with the need for ventilation, and whether there are consistent features in the brains of COVID-19 patients that could inform treatment.
Dr. Peter MacDougall
Project: A Comparison of Novel Integrated Gown, Hood and Face Shield (Halifax Gown) Personal Protective Equipment With Standard Personal Protective Equipment.
This study will test whether a new type of personal protective equipment (PPE) made in the Maritimes of reusable material can be put on faster and more safely than standard PPE.
Dr. Kenneth Rockwood
Project: Understanding How Grades of Frailty Affect the Evolution of COVID
This study will investigate how differences in frailty and fitness among people being assessed for COVID-19 are related to the development, progression, and outcomes of the disease.
Dr. Stephen Bearne
Project: Screening of CTP Synthase Inhibitors to Augment Antiviral Drugs for the Synergistic Treatment of COVID-19 Infections
This study will rapidly assess the potential of active derivatives of known antiviral drug compounds to inhibit the production of one of the building blocks the COVID-19 virus requires to replicate itself.
Dr. Stephen Beed
Project: A Device that Could Assist in Proning Anesthetized Critically Ill COVID-19 Patients
This study will develop and test a device to aid the safe repositioning of critically ill, heavily sedated, intubated, and/or pharmacologically paralyzed COVID-19 patients.
Dr. Roy Duncan
Project: Development and Evaluation of Lead DNA Vaccine Candidates for COVID-19
This study will provide the necessary pre-clinical assessment and validation of second-generation SARS-CoV-2 vaccine candidates required to meet Public Health Agency of Canada and World Health Organization guidelines for ethical first-in-human clinical assessment on an expedited timescale.
Dr. John Frampton & Mr. Gary Markle
Project: Innovations in Sustainable PPE Fabric: Local Solutions for a Global Issue
This study will develop a prototype textile that can be used to locally manufacture personal protective equipment such as surgical masks and respirators to deal with shortfalls in global supply chains.
Dr. Todd Hatchette
Project: A Multiplex Platform for Higher Sensitivity Detection of SARS-CoV2
This study will develop a new, digital droplet polymerase chain reaction (ddPCR) COVID-19 test and determine whether it is more sensitive than the existing real-time PCR test.
Dr. Morgan Langille
Project: A Microbiome-Based COVID-19 Risk-Assessment Tool
This study will identify microbes associated with COVID-19 disease severity and create and assess the accuracy of a microbiome-based COVID-19 risk assessment tool.
Dr. Craig McCormick
Project: Temperature Effects on Coronavirus Replication
This study will determine how temperature affects both coronavirus propagation and cellular response to infection, allowing for better interpretation of ongoing vaccine research.
Dr. Glenn Patriquin
Project: COVID-19 Viral Shedding Study
This study will determine the optimal upper respiratory tract specimen for detecting virus in COVID-19 patients, the point at which the virus is no longer detected in infected individuals’ upper respiratory tracts, the point at which recovered patients are no longer infectious, and how antibody titres correlate with viral shedding and disease severity.
Dr. Christopher Richardson
Project: Expression and Purification of the Spike Protein (S) of Covid19 Virus for Diagnostic Purposes and Production of Live Attenuated Viral Vaccines
This study will generate large quantities of coronavirus spike proteins that can be used to produce immune diagnostic kits and in subunit vaccines directed at COVID-19.
Dr. Ana Sjaus
Project: Development of Airborne Pathogen Containment Device for Airway Instrumentation
This study aims to protect health care workers from contracting COVID-19 by developing a device that could be placed over potentially infectious patients like a ‘bubble’ to hold infected air during intubation.
Dr. Amina Stoddart
Project: UV Disinfection Protocol for N95 Masks
This study will develop an approach to disinfect N95 masks with ultraviolet light so that they can be reused in the event of supply issues.
Dr. Jun Wang
Project: Developing a Fast-Track COVID-19 Vaccine and an Antibody ELISA Assay with High Specificity and Sensitivity
This study will determine whether a pentavalent COVID-19 vaccine can be quickly developed by formulating SARS-CoV-2 antigen with a commercial quadrivalent influenza virus vaccine.
Health Systems Improvement
Dr. Paul Amoyette
Project: Bowtie Analysis for COVID-19 Risk Reduction
This study will use a barrier-based risk management approach called Bowtie Analysis to develop a series of graphics to accurately and rapidly convey essential information on threats, consequences, prevention barriers, and mitigation barriers for the COVID-19 pandemic response.
Dr. Fred Burge
Project: Primary Care and Pandemics: How Do We Get Care to Those Who Need It?
This study will use novel data mining approaches to analyze primary care electronic medical record data in order to better meet the needs of patients during and after the pandemic.
Dr. Janet Curran
Project: Use of a Learning Health System Framework to Examine Quality and Safety Improvement at the IWK Health Centre During COVID-19 Planning
This study will use a Learning Health System framework to examine the IWK Health Centre COVID-19 pandemic planning work and identify strategies that we can use to be prepared for future pandemics.
Dr. James Hughes
Project: Employing Hyperheurisitics to Provide Direction on Deployment of COVID-19 Tests and other Interventions
This study will employ a type of artificial intelligence called a hyperheuristic to provide direction on how to deploy COVID-19 tests, vaccines, or other interventions.
Dr. Margot Latimer
Project: Identifying the Occurrence Rate and Complicating Factors Related to a COVID-19 Diagnosis in the Mi’kmaq People of Nova Scotia
This study, co-led by Mi’kmaq community health leaders, will use a Mi’kmaq-developed health data linking registry to determine the prevalence and health experience of Mi’kmaq community members in Nova Scotia diagnosed with COVID-19.
Dr. Constance MacIntosh & Dr. Matthew Herder
Project: Targeted Health Law & Policy Interventions for an Efficient, Effective and Equitable Response to COVID-19
This study will identify solutions that can be implemented to address health law- and policy-related deficiencies and gaps that have been caused or revealed by COVID-19.
Dr. Mary McNally
Project: Dalhousie Faculty of Dentistry: Guiding the Phased Reopening of Primary Oral Health Care Service Delivery in Nova Scotia During the COVID-19 Pandemic
This study will determine what changes in practice will be required to ensure a safe return of the routine delivery of oral healthcare services to the Dalhousie University Faculty of Dentistry teaching clinic and to dental practices throughout Nova Scotia.
Dr. Ashley Miller
Project: Right Care, Right Time, Right Place: Leveraging a Virtual Care Solution in the Delivery of Community-Based Care for COVID-19 Patients
This study will evaluate, refine, and implement a virtual patient-centered platform to guide COVID-19 patient care in the community, and examine clinical predictors of COVID disease progression.
Dr. Ratika Parkash
Project: Physical Distancing and Medical Distancing: Reducing the Cardiac and Neurovascular Impact of COVID‐19
This study will investigate the degree to which Nova Scotia’s COVID-19 pandemic response has affected morbidity and mortality in patients with known or new onset cardiovascular or neurovascular disease.
Dr. Nabha Shetty & Dr. Paige Moorhouse
Project: Internists Crisis Support for PCPs in LTC: making connections during COVID19
This study will develop and implement a “one stop shop” for medical specialist consultation by primary care providers working with long-term care residents to manage COVID-19 outbreaks ,with real-time evaluation of feasibility and effectiveness using an implementation science methodology.
Dr. Karthik Tennankore
Project: Prevalence and Clinical Characteristics of COVID-19 Among Hemodialysis Patients
This study will describe and compare clinical characteristics of hemodialysis patients with known or suspected exposure to COVID-19 with those of hemodialysis patients with no known or suspected exposure to COVID-19, and describe the clinical outcomes of hemodialysis patients who develop COVID-19 with those who do not.
Dr. Katie Aubrecht
Project: Evidence to Assess the Impact of COVID-19 on Community-Based Dementia Care in Nova Scotia
This study will contribute to, clarify, and enhance the best evidence-in-the-moment about programs and supports for vulnerable older adults living with dementia and their caregivers in the context of the COVID-19 pandemic.
Dr. Yigit Aydede
Project: The Role of Environmental Determinants and Social Mobility in Viral Infection Transmission in Halifax
This study will analyze the relationships between COVID-19 transmission rates, meteorological and air quality, and the fluctuations in social mobility in Nova Scotia to allow for better calibration of spatial spread in simulation models that are used to inform policy making.
Sen Dr. Wanda Thomas Bernard & Dr. Nancy Ross
Project: Culturally Responsive Healthcare to Reduce Gender Based Violence
This study will determine how lessons from the impact of COVID-19 can inform social policy and healthcare measures to better respond to gender-based violence (GBV) within the African Nova Scotian communities and how health care systems can incorporate culturally appropriate programming, resources, and services to support better responses to GBV and other adverse childhood experiences in African Nova Scotian communities.
Dr. Karen Blair & Dr. Kathryn Bell
Project: The Ties that Bind: Interpersonal Relationships as a Source of Risk and Resilience During the COVID-19 Pandemic
This study will compare Nova Scotians’ well-being and coping during the COVID-19 pandemic with other jurisdictions, assess LGTBQ+ Nova Scotians’ well-being and coping during the pandemic relative to LGBTQ+ individuals in other jurisdictions, and examine Nova Scotians’ experiences with intimate partner violence during the pandemic in comparison to other jurisdictions.
Amount: $32, 559.99
Ms. Megan Brydon
Project: The Intrapersonal Traits Associated with a Person’s Willingness to Work with COVID 19 Patients (Resilience and Empathy)
This study will measure the degrees of ‘willingness’, resilience, and empathy among medical radiation and imaging department professionals, and examine the relationship between resilience, empathy, and willingness to persevere and adapt in times of crisis.
Dr. Marsha Campbell-Yeo & Dr. Jon Dorling
Project: COVID-19 Impact of Neonatal ICU
This study will assess the needs of neonatal intensive care unit (NICU) families at the IWK Health Centre during the COVID-19 pandemic, identify barriers and facilitators to implementing virtual care options for these families during the pandemic, and evaluate one potential virtual care platform for NICU families.
Dr. OmiSoore Dryden
Project: Don’t Count Us Out!
This study will identify the determinants of trust that African Nova Scotians have with the COVID-19 pandemic strategy and response, and demonstrate how race-based data collection during the COVID-19 pandemic can establish foundational capacity to extend race-based analysis to other health and health care issues.
Dr. Debra Gilin
Project: Preventing Burnout Among Front-Line Care Workers to Fight Covid-19: Screen and Intervene
This study will rapidly develop tailored screening and intervention tools to support mental health and prevent elevated job burnout or safety risks in COVID-19-responding health care staff in Nova Scotia.
Dr. Robert Huish
Project: The Consequences and Outcomes of Cultural Stigma from COVID-19 Ordinances
This study will examine the consequences and outcomes of cultural stigma from COVID-19 ordinances in three jurisdictions of Nova Scotia, New Zealand, and Australia.
Dr. Susan Kirkland
Project: Canadian Longitudinal Study on Aging (CLSA):Building a COVID-19 Platform for Research in Canada
As part of the existing Canadian Longitudinal Study on Aging (CLSA), this study will determine individual factors that increase risk of COVID-19 symptoms and severity, understand the impact of pre-COVID factors such as socioeconomic status on health outcomes, and assess the long-term health and social consequences of COVID-19 and associated mitigation strategies on older adults.
Dr. Sandra Meier
Project: Use of an App to Determine Mental Health of Population and Health Providers During COVID
This study will link mobile sensing and clinical data to assess the impact of social distancing and counterbalancing behaviours on mental health during the COVID-19 crisis and 3 months later.
Dr. Ingrid Waldron
Project: A Culturally Specific COVID -19 Response Strategy for African Nova Scotians in the Prestons
This study will provide solution-oriented recommendations for how clinical services, health promotion, and the collection of disaggregated race-based health data can improve access to COVID-19 testing and health services, and reduce infections in the Prestons by identifying the social determinants that create exposure to and risk for COVID-19 infections and its exacerbation of current illnesses experienced by African Nova Scotians in the Prestons.
Dr. Kyly Whitfield
Project: Exploration of Potential Impacts of the COVID-19 State of Emergency Measures on Infant Feeding in Nova Scotia
This study will assess the self-perceived stress of primary caregivers of infants under 6 months old, and how the COVID-19 State of Emergency has impacted infant feeding in Nova Scotia.